| Ontology Information |
| PRO ID | PR:000000700 |
| PRO name | intermediate conductance calcium-activated potassium channel protein 4 |
| Synonyms | KCNN4 (EXACT)PRO-short-label;
IK1 (EXACT);
IKCa1 (EXACT);
KCa3.1 (EXACT);
KCa4 (EXACT);
putative Gardos channel (EXACT);
SK4 (EXACT);
SKCa 4 (EXACT);
SKCa4 (EXACT) |
| Definition | A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels. [PMID:9326665, PMID:9407042] |
| Comment | Category=gene. |
Hierarchical relationship
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Parent: PR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
Child: PR:000000753 |  | ( click to see DAG view. ) |
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