Winona C. Barker, Ph.D [PIR - Protein Information Resource]
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Winona C. Barker, Ph.D
Director Emeritus
Protein Information Resource
wb8@georgetown.edu
Primary Expertise
Dr. Barker is the Director Emeritus of Protein Information Resource at the National Biomedical Research Foundation. Her primary responsibility is to oversee scientific content of PIR databases. Her research interest is the classification of proteins into superfamilies.

Honors
1996 A Pehr Edman Award, Millipore/Methods in Protein Structure Analysis

Education
B.A., Zoology, Connecticut College, New London, CT. 1959
Ph.D., Physiology, University of Chicago, Chicago, IL. 1966
Post-Doc, Mathematical Biology, University of Chicago, Chicago, IL. 1967

Publications
UniProt Consortium (2007). The Universal Protein Resource (UniProt). Nucleic Acids Res. 35(Database issue):D193-197.
Natale D.A., Arighi C.N., Barker W.C., Blake J., Chang T., Hu Z.Z., Liu H., Smith B., Wu C.H. (2006). Framework for a Protein Ontology Proceedings of ACM First International Workshop on Text Mining in Bioinformatics, TMBIO 2006.
Nikolskaya A.N., Arighi C.N., Huang H., Barker W.C., Wu C.H. (2006). PIRSF Family Classification System for Protein Functional and Evolutionary Analysis. Evolutionary Bioinformatics Online 2, 209-221.
Wu, C.H., Apweiler, R., Bairoch, A., Natale, D.A., Barker, W.C., Boeckmann, B., Ferro, S., Gasteiger, E., Huang, H., Lopez, R., Magrane, M., Martin, M.J., Mazumder, R., O'donovan, C., Redaschi, N., Suzek, B. (2006). The Universal Protein Resource (UniProt): an expanding universe of protein information. Nucleic Acids Research, 34, D187-91.
Bairoch, A., Apweiler, R., Wu, C. H., Barker, W. C., Boeckmann, B., Ferro, S., Gasteiger, E., Huang, H., Lopez, R., Magrane, M., Martin, M.J., Natale, D.A., O'Donovan, C., Redaschi, N., Yeh, L.S. (2005). The Universal Protein Resource (UniProt). Nucleic Acids Research, 33: D154-159.
Wu, C.H., Huang, H., Nikolskaya, A., Hu, Z. and Barker, W. C. (2004). The iProClass integrated database for protein functional analysis. Computational Biology and Chemistry, 28, 87-96.
Wu, C. H., Nikolskaya, A., Huang, H., Yeh, L.-S., Natale, D., Vinayaka, C. R., Hu, Z., Mazumder, R., Kumar, S., Kourtesis, P., Ledley, R. S., Suzek, B. E., Arminski, L., Chen, Y., Zhang, J., Cardenas, J. L., Chung, S., Castro-Alvear, J., Dinkov, G. and Barker, W. C. (2004). PIRSF family classification system at the Protein Information Resource. Nucleic Acids Research, 32, D112-114.
Apweiler R, Bairoch A, Wu, C. H., Barker, W. C., Boeckmann, B., Ferro1, S., Gasteiger, E., Huang, H., Lopez, R., Magrane, M., Martin, M. J., Natale, D. A., O Donovan, C., Redaschi, N., Yeh, L. S. (2004). UniProt: Universal Protein Knowledgebase. Nucleic Acids Research, 32, D115-119.
Wu, C. H., Yeh, L.-S., Huang, H., Arminski, L., Castro-Alvear, J., Chen, Y., Hu, Z., Kourtesis, P., Ledley, R. S., Suzek, B.E., Vinayaka, C.R., Zhang, J. and Barker, W. C. (2003). The Protein Information Resource. Nucleic Acids Research, 31, 345-347.
Huang, H., Barker, W. C., Chen, Y. and Wu, C. H.(2003). iProClass: An Integrated Database of Protein Family, Function, and Structure Information. Nucleic Acids Research, 31, 390-392.
Wu, C. H., Huang, H., Yeh, L.-S. and Barker, W. C. (2003). Protein family classification and functional annotation. Computational Biology and Chemistry, 27, 37-47.
Wu, C.H., Huang, H., Arminski, L., Castro-Alvear, J., Chen, Y., Hu,Z. Z., Ledley, R. S., Lewis, K. C., Mewes, H., Orcutt, B. C., Suzek, B. E., Tsugita, A., Vinayaka, C. R., Yeh, L. S., Zhang, J., Barker, W. C. (2002). The Protein Information Resource: an integrated public resource of functional annotation of proteins. Nucleic Acids Research, 30, 35-37.
Barker, W. C., et al. and C. H. Wu. (2001). The Protein Information Resource. Nucleic Acids Research, 29, 29-32.
Wu, C., Xiao, C., Hou, Z., Huang, H., Barker, W.C. Nucleic Acids Res.(2001) iProclass: an integrated, comprehensive and annotated protein classification database.29, 52-54.
E.E. Abola, A. Bairoch, W.C. Barker, et.al. (2000) Quality Control in Databanks for Molecular Biology, BioEssays.
Barker, W. C., et al. and C. H. Wu. (2000). The Protein Information Resource. Nucleic Acids Research, 28, 41-44.
P.B. McGarvey, H. Huang, W.C. Barker, B.C. Orcutt, J.S. Garavelli, G.Y. Srinivasarao, L-S.L. Yeh, C. Xiao, and C.H. Wu. (2000) PIR: a new resource for bioinformatics, Bioinformatics, 16: 290-291.
G.Y. Srinivasarao, L.-S.L. Yeh, C.R. Marzec, B.C. Orcutt, and W.C. Barker (1999) PIR-ALN: A Database of Protein Sequence Alignments, Bioinformatics, 15: 382-390.
G.Y. Srinivasarao, L-S.L. Yeh, C.R. Marzec, B.C. Orcutt, W.C. Barker, and F. Pfeiffer. (1999) Database of protein sequence alignments: PIR-ALN, Nucleic Acids Research, 27: 284-285.
W.C. Barker, J.S. Garavelli, P.B. McGarvey, C.R. Marzec, B.C. Orcutt, G.Y. Srinivasarao, L-S.L. Yeh, R.S. Ledley, H.-W. Mewes, F. Pfeiffer and A. Tsugita (1999) The PIR-International Protein Sequence Database, Nucleic Acids Research, 27: 39-43.
C. Wu, S. Zhao and W.C. Barker, (1997) Family Identification System for Electron Transfer Proteins Using a Motif Neural Network Design, Pept. Lett., 4: 279-285.
W.C. Barker, F. Pfeiffer and D.G. George (1996) The Superfamily Classification in the PIR-International Protein Sequence Database, Methods in Enzymology, R.F. Doolittle, ed., Academic Press, Orlando, FL. pp. 59-71.

W.C. Barker, F. Pfeiffer, and D.G. George (1995) Superfamily and Domain: Organization of Data for Molecular Evolution Studies, Methods in Protein Structure and Analysis. M.Z. Atassi and E. Appella, eds., Plenum Publishing, New York, pp. 473-481.


Revised 07/13/07

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