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PRO is a formal representation of protein objects, providing both descriptions of these objects and the relationships between them ( current release: 6.0, version 1 ).
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PRO encompasses a sub-ontology of proteins based on evolutionary relatedness (ProEvo) and a sub-ontology of the multiple protein forms produced from a given gene (ProForm). PRO is interoperable with other OBO Foundry ontologies--such as the Sequence Ontology (SO) and the Gene Ontology (GO)--that provide representations of protein qualities. This interoperability facilitates cross-species comparisons, pathway analysis, disease modeling, and the generation of new hypotheses through data integration and machine reasoning.

 Explanation of the figure
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