Education
	B.S., Recombinant Gene Technology, State University of New York, Fredonia, NY. 1986
	Ph.D., Molecular and Cellular Biology, Roswell Park Cancer Institute, SUNY Buffalo, NY. 1993
	Post Doctorate, Roche Institute of Molecular Biology, Nutley, NJ. 1996
	Post Doctorate, Nat'l Institute of Child Health and Human Dev., National Institutes of Health, Bethesda, MD. 1999

Publications
C.H. Wu, R. Apweiler, A. Bairoch, D.A. Natale, W.C. Barker, B. Boeckmann, S. Ferro, E. Gasteiger, H. Huang, R. Lopez, M. Magrane, M.J. Martin, R. Mazumder, C. O'donovan, N. Redaschi, B. Suzek. The Universal Protein Resource (UniProt): an expanding universe of protein information. Nucleic Acids Res. 34: D187-91. 2006.
R. Mazumder, D.A. Natale, S. Murthy, R. Thiagarajan, C.H. Wu. Computational identification of strain-, species- and genus-specific proteins. BMC Bioinformatics 6: 279. 2005.
Bairoch, R. Apweiler, C.H. Wu, W.C. Barker, B. Boeckmann, S. Ferro, E. Gasteiger, H. Huang, R. Lopez, M. Magrane, M.J. Martin, D.A. Natale, C. O'Donovan, N. Redaschi, L.-S. Yeh. The Universal Protein Resource (UniProt). Nucleic Acids Res. 33:D154-9. 2005.
E.V. Koonin, N.D. Fedorova, J.D. Jackson, A.R. Jacobs, D.M. Krylov, K.S. Makarova, R. Mazumder, S.L. Mekhedov, A.N. Nikolskaya, B.S. Rao, I.B. Rogozin, S. Smirnov, A.V. Sorokin, A.V. Sverdlov, S. Vasudevan, Y.I. Wolf, J.J. Yin, and D.A. Natale. A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes. Genome Biol. 52:R7. 2004.
R. Apweiler, A. Bairoch, Wu. C.H., Barker, W.C., Boeckmann, B., Gasteiger, E., Huang, H., Martin, M.J., Natale, D. A., O Donovan, C., Yeh, L.-S. UniProt: Universal Protein Knowledgebase. Nucleic Acids Res. 32, D115-119. 2004.
C.H. Wu, A. Nikolskaya, H. Huang, L.-S. Yeh, D.A. Natale, C.R. Vinayaka, Z. Hu, R. Mazumder, S. Kumar, P. Kourtesis, R.S. Ledley, B.E. Suzek, L. Arminski, Y. Chen, J. Zhang, J.L. Cardenas, S. Chung, J. Castro-Alvear, G. Dinkov, and W.C. Barker. PIRSF family classification system at the Protein Information Resource. Nucleic Acids Res. 32, D112-114. 2004.
I.B. Rogozin, V.N. Babenko, N.D. Fedorova, J.D. Jackson, A.R. Jacobs, D.M. Krylov, K.S. Makarova, R. Mazumder, S.L. Mekhedov, B.G. Mirkin, A.N. Nikolskaya, B.S. Rao, S. Smirnov, A.V. Sorokin, A.V. Sverdlov, S. Vasudevan, Y.I. Wolf, J.J. Yin, D.A. Natale, and Koonin, E.V. Evolution of eukaryotic gene repertoire and gene structure: discovering the unexpected dynamics of genome evolution. Cold Spring Harb Symp Quant Biol. 68:293-301. 2003.
R.L. Tatusov, N.D. Fedorova, J.D. Jackson, A.R. Jacobs, B. Kiryutin, E.V. Koonin, D.M. Krylov, R. Mazumder, S.L. Mekhedov, A.N. Nikolskaya, B.S. Rao, S. Smirnov, A.V. Sverdlov, S. Vasudevan, Y.I. Wolf, J.J. Yin, and D.A. Natale. The COG database: an updated version includes eukaryotes. BMC Bioinformatics 4:41. 2003.
A.I. Slesarev, K.V. Mezhevaya, K.S. Makarova, N.N. Polushin, O.V. Shcherbinina, V.V. Shakhova, G.I. Belova, L. Aravind, D.A. Natale , I.B. Rogozin, R.L. Tatusov, Y.I. Wolf, K.O. Stetter, A.G. Malykh, E.V. Koonin, and S.A. Kozyavkin: The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens. Proc Natl Acad Sci USA 99:4644-9. 2002.
R.L. Tatusov, D.A. Natale , I.V. Garkavtsev, T.A. Tatusova, U.T. Shankavaram, B.S. Rao, B. Kiryutin, M.Y. Galperin, N.D. Fedorova, and E. V. Koonin: The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res. 29:22-8. 2001.
I.K. Jordan, D.A. Natale , E.V. Koonin, and M.Y. Galperin: Independent evolution of heavy metal-associated domains in copper chaperones and copper- transporting atpases. J Mol Evol. 53:622-33. 2001.
D.A. Natale , M.Y. Galperin, R.L. Tatusov, and E.V. Koonin: Using the COG database to improve gene recognition in complete genomes. Genetica 108:9-17. 2000.
I.K. Jordan, D.A. Natale , and M.Y. Galperin: Copper chaperones in bacteria: association with copper-transporting ATPases. Trends Biochem Sci. 25:480-1. 2000.
D.A. Natale , Shankavaram U.T., M.Y. Galperin, Y.I. Wolf,L. Aravind, and E.V. Koonin: Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs). Genome Biol. 1:RESEARCH0009. 2000.
M.Y. Galperin, D.A. Natale , L. Aravind, and E.V. Koonin: A specialized version of the HD hydrolase domain implicated in signal transduction. J Mol Microbiol Biotechnol. 1:303-5. 1999.
D.A. Natale , R.M. Umek, and D. Kowalski: Ease of DNA unwinding is a conserved property of yeast replication origins. Nucleic Acids Res. 21: 555-560. 1993.
D.A. Natale , A.E. Schubert, and D. Kowalski: DNA helical stability accounts for mutational defects in a yeast replication origin. Proc. Natl. Acad. Sci. USA 89: 2654-2658. 1992.
D.A. Natale , C.J. Li, W.H. Sun, and M.L. DePamphilis: Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. EMBO J. 19:2728-38. 2000.
C.J. Li, J.A. Bogan, D.A. Natale , and M.L. DePamphilis: Selective activation of pre-replication complexes in vitro at specific sites in mammalian nuclei. J Cell Sci. 113:887-98. 2000.
J.A. Bogan, D.A. Natale , and M.L. DePamphilis: Initiation of eukaryotic DNA replication: conservative or liberal? J Cell Physiol. 184:139-50. 2000.
D. Kowalski, D.A. Natale , and M.J. Eddy: Stable DNA unwinding, not "breathing," accounts for single-strand-specific nuclease hypersensitivity of specific A+T-rich sequences. Proc. Natl. Acad. Sci. USA 85: 9464-9468. 1988.

Revised 03/25/05